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This alteration suppressed GATA3 expression via the bile acid-Takeda G protein-coupled receptor 5(TGR5)-cyclic adenosine monophosphate (cAMP) signaling pathway, leading to a marked ~90% reduction in IL-22 secretion from intestinal group 3 innate lymphoid cells (ILC3s), which subsequently induced insulin resistance, ovarian dysfunction (characterized by increased follicular cysts and decreased corpora lutea), and impaired fertility (82)

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Pivotal roles for pH, lactate, and lactate-utilizing bacteria in the stability of a human colonic microbial ecosystem

10.1016/j.foodchem.2023.137108 Food Chem